Throat cancer of the nasopharynx located at the upper part of the throat and behind the nose. According to the National Cancer Institute in 2009 there were 12,610 cases reported out of those were 2,230 deaths from the disease.
A study done by the Genome Institute of Singapore, biomedical research institute of the Agency for Science, Technology and Research (A*STAR) and the Sun Yat-Sen University Cancer Center. Scientists from China, Singapore and USA participated in this study. That led scientists to distinguish three new sensitive genes in the genome wide association study of nasopharynx carcinoma (NPC).
NPC cancer is especially common in southern China at developing rates of 25 times higher than most of the regions in the world. Due to that factor is called Cantonese Cancer. The study managed by Dr. Liu Jianjun, Associate Director and Senior Group Leader of Human Genetics at GIS along with Professor Yi-Xin Zeng, President of the Sun Yat-sen University Cancer Center. The conclusions of this study are published in Nature Genetics May 30, 2010.
The scientists had carried out a extensive genetic analysis of the human genome in a immense clinical sample of southern Chinese descent, 5,000 patients and 5,000 controls. Researchers findings of genetic variations contained in human leukocyte antigen (HLC) along with three genes referred to as TNFRSFI9, MDSIEVI1, and CDKNZA/2B can greatly control a persons chance of getting NPC. Researchers also acknowledged that the three genes for NPC also have been related to the association in the development of leukemia. This therefore, purposes there possibly can be some common biological structure between the events of these two diseases. This discovery gives a vital connection for biologists to comprehend the molecular functioning concealed in the development of this cancer, along with its surprising dominance in southern China.
Dr. Jianjuan stated even though many groups have tried identification of the genetic risk factors in NPC, the results from past studies were hampered by the tiny number of genes and clinical samples used. Due to the fact this study had 10,000 subjects, they were able to arrive with more substantial proof than other previous studies.
Professor Zeng interjected the results proved strong genetic effect of HLA locus in the risk of NPC.
With applying high density genetic markers, the conclusions aide to decrease the search in the chromosome area for the gene causing alternatives linked with HLA loci. Being able to diagnose deficient genes affected with the risk of NPC, will aide to establish a copy for risk prediction and screen for extreme risk populations.
There is no more need to conduct any further studies of HLA associations. The task at hand now is determine the area that is within or outside of HLA complex which hides the genetic links or links and to establish if the genetic change is needed to be present on both chromosomes.
The most sought after alternative treatment to cancer is Chinese Medicine. It has vast advantages to deal with the most common complications of the disease. It also helps to fight side effects from various treatments of Western medicine such as chemotherapy.
A study conducted in Hong Kong showed that Chinese medicine including acupuncture, herbal medicine, therapeutic massage and Chinese dietary therapy should be incorporated into Western medicine treatments.
National Cancer Institute
Chinese Medicine Journal