Yale University, Connecticut, conducted a brand new study and discovered that an ancient Chinese four herb remedy defined 18,000 years earlier, lessens the gastrointestinal toxicity and advanced the anti tumor reaction from the chemotherapy medication CPT-11(irinotecan) in mice who had colon cancer.
In the August 18th journal Science Translation Medicine is the published paper of this study.
Dr. Yung-Chi “Tommy” Cheng, Henry Bronson, professor of pharmacology at Yale University and co-director of the University Cancer Center’s Developmental Therapeutics, and senior writer of the study had co-discovered the formula referred to as PHY906. Dr. Cheng and Yale University both have financial interests in the company which is developing the formula.
Dr. Cheng had announced to the press that chemotherapy creates considerable anguish in millions of patients however, PHY906 has numerous biological working combinations which can respond to numerous causes of pain.
PHY906 is made up of four herbs and is established on a herbal recipe referred to in China as Huang Qin Tang, that was first used in the treatment of nausea, vomiting and diarrhea dating back 1,800 years.
Dr. Chang and his associates made the decision to examine the herbal formulas capability to decrease gastrointestinal reactions to a usually used chemotherapy medication without altering it’s capability to destroy cancer cells.
Researchers had discovered that after the mice with colon cancer who had been getting treatments of chemotherapy CPT11, had received PHY906, the mice had witnessed lessened toxicity, had less weight loss, and displayed a greater anti-tumor activity than in alike mice that had not received the formula. The formula also advocated new intestinal cell growth.
The PHY906 however, could not guard against the onset of DNA damage and apoptosis set off by CPT11 in the intestine, however within four days after CPT11 treatment, PHY906 had rejuvenated the intestinal epithelium by encouraging the development of stem cells and a many Wnt signaling components the researchers had written.
The PHY906 seemed to decrease inflammation in the mice through lessening the invasion of neutrophils or macrophages along with reduction of expression of a tumor necrosis factor within the intestine, and the inflammation causing cytokine absorption in plasma.
In a additional experiment researchers had demonstrated that PHY906 also had activated the activity of a certain Wnt protein (Wnt3a) in human embryonic kidney-293 cells.
Wnt proteins are a massive network of cell to cell signaling molecules essential to embryo growth and whose interruption recognized to lead to cancer.
The researchers final decision was that the herbal medicine PHY906 has the ability to offset the toxicity of CPT11 through a couple components that act at the same time.
Dr. Chang had stated the mix of chemotherapy and herbs exhibits a union of Western and Eastern methods for the treatment of cancer.
Although in an associated editorial “Are Herbal Medicines Ripe For The Cancer Clinic?” Dr. Cathy Eng, of the Department of Gastrointestinal Medical Oncology at the University of Texas MD Anderson Cancer Center in Houston, cautions that several challenges need to be defeated prior to the formulas use in humans.
When upon deciding of the use of complimentary and alternative medicines (CAM) regarding the treatment of cancer patients Dr. Eng had written that a person must take into regard the reproduction of preclinical results in clinical practice, quality guarantee of herbal products along with possible toxicities linked with alternative treatments.
This study had been financed by National Cancer Institute of the National Institutes of Health (NIH).
There are many persons who use alternative treatments to help them deal with the side effects that chemotherapy and radiation can produce. It is estimated that at least 54% of cancer patients use the alternative treatments to help alleviate side effects from chemotherapy. Some of them are listed below.
In traditional Chinese Medicine there are numerous treatments used to help with the side effects of chemotherapy.
Chinese herbs such as Peony (Bia Shao) and honeysuckle (Jin Yin Hua) are used to help tonifying energy, providing nourishment to the blood and clearing toxic heat.
Acupuncture or acupressure upon the points of Neiguan whose location is two inches above the wrist is very useful to rid vomiting and nausea.
An article which is in the archives of Physical Medicine and Rehabilitation 2005 showed that chiropractic manipulation had the highest success rate for pain treatment at 7.33 out of 10.
Ganoderma a hard bitter mushroom used in Chinese medicine. It is used as a supplement during chemotherapy to decrease tiredness, appetite loss, suppressed bone marrow and infections. It also lessens the toxic side effects.
Glutamine supplements helps reduce the inflammation which appears in the mouth due to chemotherapy treatments and may also help lessen diarrhea symptoms.
Astragalus is an ancient Chinese herbs that most often is used with other herbs. It aides in strengthening the body and it contains anti-bacterial and anti-inflammatory properties. It aides in activating the immune system which is jeopardized by chemotherapy treatments.
Ginger helps with the nausea and vomiting of the chemotherapy treatments.
Echinacea will aide in heightening the immune system which is hampered from the chemotherapy.
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